Kouhei Tsumoto Professor
Satoru Nagatoishi Project Associate Professor
Makoto Nakakido Lecturer
Ryo Matsunaga Assistant Professor
Biological phenomena are based on highly organized and specific molecular interactions. We aim to dissect these biomolecular interactions using state-of-the-art methodologies, and to design ligands to control them. We also advance bio-medicine in the era of bio-better and bio-superior using multiple engineering approaches. Our methodologies are applied to the study of disease-related biological machineries and will stimulate the creation of safer and more efficient medications.
Integrated Biometal Science (IBmS) :
Biometals elaborate functions of biomolecules. Understanding of relationships between protein functions and biometals deepen the understanding of “Life system” and lead to development of novel therapeutics for a variety of diseases.
Next Generation Antibody engineering :
Fundamental research on the next generation of antibody design through protein engineering and rational strategies based on their physicochemical and cellular properties.
Artificial regulation of biomolecular interactions :
Screening and optimization of fragment-based molecules to modulate biomolecular interactions. These works are conducted in partnership with the Drug Discovery Initiative (DDI) of The University of Tokyo.
Focus on disease-related molecular systems :
Unraveling the molecular and physicochemical basis of bio-systems that strengthen disease, and using that knowledge to fight pathogenic microorganisms and the plague of cancer with different modality-based molecules.
Computational chemistry and biology for molecular design :
Developing computational methods for analysis and design of molecular interactions, and applying the methods in wet-lab experiments.