Research

Biological phenomena are based on highly organized and specific molecular interactions. We aim to dissect these biomolecular interactions using state-of-the-art methodologies, and to design ligands to control them. We also advance bio-medicine in the era of bio-better and bio-superior using multiple engineering approaches. Our methodologies are applied to the study of disease-related biological machineries and will stimulate the creation of safer and more efficient medications.

Integrated Biometal Science (IBmS) :

Biometals elaborate functions of biomolecules. Understanding of relationships between protein functions and biometals deepen the understanding of “Life system” and lead to development of novel therapeutics for a variety of diseases.

Next Generation Antibody engineering :

Fundamental research on the next generation of antibody design through protein engineering and rational strategies based on their physicochemical and cellular properties.

Artificial regulation of biomolecular interactions :

Screening and optimization of fragment-based molecules to modulate biomolecular interactions. These works are conducted in partnership with the Drug Discovery Initiative (DDI) of The University of Tokyo.

Focus on disease-related molecular systems :

Unraveling the molecular and physicochemical basis of bio-systems that strengthen disease, and using that knowledge to fight pathogenic microorganisms and the plague of cancer with different modality-based molecules.

Computational chemistry and biology for molecular design :

Developing computational methods for analysis and design of molecular interactions, and applying the methods in wet-lab experiments.

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