Research

We are conducting a broad range of research with a focus on antibody engineering, integrating advanced physicochemical analysis techniques and computational science technologies with a view to drug discovery and materials development. Based on precise interaction analysis at the molecular level, we aim to pioneer the next generation of biotechnology.

Next-Generation Antibody Engineering :

Antibodies are widely used as biopharmaceuticals and diagnostics due to their excellent antigen recognition capabilities, and there is a demand for their enhanced functionality and properties. We are promoting basic research in next-generation antibody engineering using protein engineering, physicochemical analysis and cell biological analysis. We are working on research to accelerate antibody drug development by elucidating the molecular mechanisms of antibody antigen recognition and incorporating the latest technologies such as high-throughput screening and data-driven design.

Molecular Machinery Elucidation of Disease-Related Proteins :

Focusing on pathogenic microorganisms and brain, nerve and cancer-related proteins, we are advancing the structural and functional analysis of protein complexes that cause disease, as well as the development of control technologies using modalities such as antibodies, mid-sized molecules and small molecules.

Bio-metal Science :

Metals are essential for the functional expression of proteins, and abnormalities in their regulation can lead to disease. We are analyzing the interactions between proteins and metals in living organisms in detail, with the aim of finding applications in the treatment of diseases and the development of new antibacterial drugs through metal-mediated functional control of proteins.

Development of Bio-molecular Interaction Control Agents :

We are engaged in the discovery and optimization of small molecules that can control the interactions of life molecules, with the goal of creating functional reagents that contribute not only to drug discovery but also to life science research, in close collaboration with the Drug Discovery Initiative (DDI) of our university.

Protein Engineering for Biomaterials :

Focusing on the advanced self-assembly and specific molecular recognition capabilities of proteins, we aim to develop new biomaterials that can be applied in a wide range of fields, including pharmaceuticals, energy, environment and materials, through precise redesign of amino acid sequences.

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