Molecular Design Group

Department of Chemistry & Biotechnology, Faculty of Engineering, The University of Tokyo
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo

http://park.itc.u-tokyo.ac.jp/moldes/

  Associate Professor
Takeshi Wada

Recent Publications

  • Chem. Soc. Rev. 2011, 40, 5829-5843. [PDF]
  • J. Org. Chem. 2011, 76, 5895–5906. [PDF]
  • Angew. Chem. Int. Ed. 2009, 48, 496–499. [PDF]
  • Chem. Commun. 2009, 2466–2468. [PDF]

Research

We conduct research on nucleic acids, sugar and other biomolecules with complicated structrures. Our main focus lies on chemically modifying these molecules to render them with better functional properties so that they could be used as therapeutic agents or biomaterials.

Chemcial synthesis of nucleic acid therapeutics :

We design and synthesize artificial nucleic acids or peptides that can bind to complementary DNA or mRNA in target-specific ways to silence specific genes.

Synthesis of functional oligosaccharides :

We aim at synthesizing oligosaccharides that bear new kind of structures and exhibit interesting biochemical properties, such as target-specific binding with other biomolecules.

Chirality control of heteroatoms :

We carry out stereoregulated synthesis of the biomolecules bearing hetroatoms like phosphorous or silicon in an asymmetric environment. Using these stereoregulated biomolecules, we intend to produce new kinds of functional materials or biomaterials.