The Tsumoto Group
Physical Biochemistry

Department of Chemistry & Biotechnology
School of Engineering, The University of Tokyo

Kouhei Tsumoto
  Associate Professor
Satoru Nagatoishi
Assistant Professor
Makoto Nakakido
Assistant Professor
Daisuke Kuroda

Recent Publications

  • Sci. Rep. 2017, 7, 39518. [PDF]
  • Sci. Rep. 2015, 5, 15337. [PDF]
  • Nat. Commun. 2015, 6, 6866. [PDF]
  • Nat. Commun. 2015, 6, 6337. [PDF]


Biological phenomena are based on highly organized and specific molecular interactions.  We aim to dissect these biomolecular interactions using state-of-the-art methodologies, and to design ligands to control them.  We also advance bio-medicine in the era of bio-better and bio-superior using multiple engineering approaches. Our methodologies are applied to the study of disease-related biological machineries and will stimulate the creation of safer and more efficient medications.

Antibody engineering in the era of Bio-better :

Fundamental research on the next generation of antibody design through protein engineering and rational strategies based on their physicochemical and cellular properties.

Artificial regulation of biomolecular interactions :

Screening and optimization of fragment-based molecules to modulate biomolecular interactions. These work is conducted in partnership with the Drug Discovery Initiative (DDI) of The University of Tokyo.

Focus on disease-related molecular systems :

Unraveling the molecular and physicochemical basis of bio-systems that strengthen disease, and using that knowledge to fight pathogenic microorganisms and the plague of cancer.

Protein engineering in Bio-material design :

Engineering and development of novel strategies to manipulate biological molecules, and creation of bio-inspired structures based on natural scaffolds and bioactive machines.