The Suzuki Group
RNA biochemistry

Department of Chemistry & Biotechnology
Faculty of Engineering / School of Engineering, The University of Tokyo

http://rna.chem.t.u-tokyo.ac.jp/

  Professor
Tsutomu Suzuki
  Lecturer
Takeo Suzuki
 

Assistant Professor
Asuteka Nagao
 

Assistant Professor
Takayuki Ohira

Recent Publications

  • Nature Struct. Mol. Biol. 2017, in press. [PDF]
  • Nature Chem. Biol. 2016, 12, 648-655. [PDF]
  • Nature Chem. Biol. 2016, 12, 546-551. [PDF]
  • Nature Rev. Genet. 2016, 17, 365-372. [PDF]

Research

Non-coding RNAs have emerged as regulatory elements of gene expression, to control higher ordered biological processes such as development, differentiation and complicated mental activity. We aim to unveil a hidden layer of regulatory mechanism for gene expression involved in various biological processes by exploring qualitative information embedded in cellular RNA molecules using our highly sensitive detection technique of mass spectrometry.

Ribonucleome- a world of RNA modifications :

Ribonucleome is a concept for comprehensive approach to embrace molecular aspects of RNAs. We aim to study gene expression modulated by RNA modification  (RNA editing), and human diseases caused by disorder of RNA modifications.

Molecular mechanism of protein synthesis and functional analysis of ribosome :

Ribosome is a sophisticated machinery that synthesizes proteins. Ribosomal RNAs play crucial roles in protein synthesis. Weユve been studying architectural and functional aspects of ribosomal RNAs.

MicroRNA and RNA interference :

MicroRNAs are small non-coding RNAs that repress gene expression specifically. Our research aims to study biogenesis and metabolism of microRNAs to reveal modulatory mechanism of gene expression involved in various biological processes.