The Sando Group
Chemical Biology

Department of Chemistry & Biotechnology
Faculty of Engineering / School of Engineering, The University of Tokyo

http://park.itc.u-tokyo.ac.jp/sandolab/index_e.html

  Professor
Shinsuke Sando
  Lecturer
Hiroshi Nonaka
  Assistant Professor
Jumpei Morimoto
  Assistant Professor
Ryosuke Ueki

Recent Publications

  • Sci. Rep. 2017, 7, 40104. [PDF]
  • Angew. Chem. Int. Ed. 2016, 55, 10626-10629. [PDF]
  • Angew. Chem. Int. Ed. 2016, 55, 1765-1768. [PDF]
  • Angew. Chem. Int. Ed. 2016, 55, 579-582. [PDF]

Research

Our body is composed of a variety of biomolecules. An unsolved principle of life must lay in the activities of such biomolecules and the abnormal molecular activities could cause various diseases such as metabolic disorder. Our group is conducting chemistry-based research for "understanding of living systems at the molecular level" and "developing new molecular technology contributing to early diagnosis and therapy". The research area ranges from leading edge sensing technology for non-invasive molecular diagnosis/analysis/sensing and functional molecule development for molecular therapy and regenerative therapy.

Molecular Technologies for the analysis of biomolecules in vivo:

We conduct research toward sensitive "molecule" sensing technologies that allow us to analyze molecular activities in vivo: structural change, chemical reaction, and dynamics. These new molecular technologies will be innovative tools for basic life science and will pave the way for future medical care including early diagnosis.

Synthetic molecules for regulation of cellular functions:

We have engaged in synthetic molecules that can control activity and fate of the cells. The synthetic materials would be good replacement of natural protein, including growth factors and cytokines, in terms of production cost, quality control and chemical stability. We are trying to develop a new biotechnologies that would contribute to regenerative therapy and cell engineering.

Rational design and high-throughput screening of synthetic molecules for drug discovery:

Our goal is development of bioactive compounds that can be utilized as drug leads and molecular tools for biological studies. Our strategy toward this goal is a combination of rational designs of chemical structure and high-throughput screening of synthetic compound libraries. We envision that this research will reveal fundamental structural elements for producing bioactive compounds of strong and selective biomolecular recognition and high membrane permeability.