The Nagamune Group
Cell & Protein Engineering

Department of Chemistry & Biotechnology
Faculty of Engineering / School of Engineering, The University of Tokyo

http://park.itc.u-tokyo.ac.jp/nagamune/

  Professor
Teruyuki Nagamune
  Associate Professor
Masahiro Kawahara
  Assistant Professor
Hidehiko Hirakawa

Recent Publications

  • Adv. Healthcare Mater. 2016, 5, 1002-1007. [PDF]
  • Angew. Chem. Int. Ed. 2016, 55, 15002-15006. [PDF]
  • Biotechnol. Bioeng. 2016, 113, 1113–1123. [PDF]
  • Biomacromol. 2016, 17, 1978-1984. [PDF]

Research

Recent progress of molecular cell biology has been revealing structures and functions of various biomolecules.ハ Based on hot biological findings, we aim to apply functions of cell and biomolecules to various engineering fields using techniques, which includes protein engineering, genetic engineering and organic synthesis.

Controlling cell fate using chimeric receptors :

Ligand-binding domain of cytokine receptors is replaced with antibody variable regions, aiming at a system to control cellular fate in response to a cognate antigen .

Regulating the functions of biomolecules with synthetic small molecules :

Our research aims to develop chemical tools for regulating the functions of biomolecules in vivo by modifying peptides or nucleotides with stimuli-responsive small molecules.

Cell surface modification for regulation and analysis of cellular functions :

Enzyme-mediated labeling of membrane proteins is applied to analysis and regulation of their functions. Cell surface display method with membrane anchoring reagents is applied to cancer immunotherapy and cell patterning.

Nano-scaled protein engineering :

We design and create non-natural functional proteins using nanometre-scaled protein/enzyme engineering.