The Kudo Group
Green Organic Chemistry

Department of Chemistry & Biotechnology
School of Engineering, The University of Tokyo

http://www.iis.u-tokyo.ac.jp/~kkudo/

  Professor
Kazuaki Kudo
  Research Associate
Kengo Akagawa

Recent Publications

  • J. Org. Chem. 2016, 61, 9396-9401. [PDF]
  • Chem. Lett. 2016, 45, 300-302. [PDF]
  • Eur. J. Org. Chem. 2015, 5055-5059. [PDF]
  • Angew. Chem. Int. Ed. 2015, 54, 1822-1826. [PDF]

Research

Peptides are made of amino acids and currently used as peptide drugs and supplements. We think that peptides are potentially applicable for the development of catalysts and functional materials. We propose a new field of peptide chemistry.

Highly selective peptide organocatalysts :

Enzymes catalyze reactions with high efficiency and high selectivity under mild conditions in water based on their three dimensional molecular structures. By mimicking such a machinery, we are developing peptide catalysts having specific secondary structures with focusing on regio- or chemoselectivity.

Organocatalyst design based on peptides :

Peptides are synthesized by sequential introduction of amino acid derivatives on resins. The chemicals used for such synthesis are expensive and not suitable for large-scale production. We are developing structurally simple organocatalysts by extracting the indispensable elements of peptide catalysts.

Synthesis of biologically-active compounds by mimicking biosynthetic :

Pathways Living organisms make a variety of bioactive compounds in which many drug / drug candidate molecules are included. Such compounds have already been chemically synthesized, however, the synthetic methods often suffer from problems in safety, cost, and environmental impact. We are developing general synthetic methods for such compounds based on biosynthetic mechanisms.