The Ikeuchi Group
Biomolecular and Cellular Engineering

Department of Chemistry & Biotechnology
School of Engineering, The University of Tokyo

http://www.bmce.iis.u-tokyo.ac.jp/

  Lecturer
Yoshiho Ikeuchi

Recent Publications

  • Cell Reports 2013, 12, 879-889. [PDF]
  • J. Biol. Chem. 2014, 289, 25067-25078. [PDF]
  • Nat. Chem. Biol. 2010, 6, 277-282. [PDF]
  • J. Neurosci. 2009, 29, 4312-4321. [PDF]

Research

To understand brain development and fight against brain diseases, we are investigating how neurons and brains form their unique shape/morphology.

Understanding mechanisms underlying morphology of neurons :

Morphology of neurons is fundamental component for circuitry formation in brain. Protein synthesis is strictly controlled during neuronal development to achieve normal morphogenesis. Disruption of protein synthesis regulation results in developmental brain diseases including autism spectrum disorders and epilepsy. We are investigating roles of protein synthesis regulation in neuronal morphology with biochemical and bioengineering techniques to contribute development of cure for the diseases. We are also developing genetic tools to observe and manipulate protein synthesis locally within a cell.

Understanding mechanisms underlying morphology of brains :

Brain has a complex morphology comprised of functionally different multiple parts. We are investigating mechanisms of compartmentalization of brain by locally stimulating brain organoids with various bioactive chemical compounds.