The Gotoh Group
Cell Technology

Graduate School of Pharmaceuticeal Sciences, The University of Tokyo

http://www.iam.u-tokyo.ac.jp/celltech/

Gotoh lab has moved to Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Please visit their new homepage: http://www.f.u-tokyo.ac.jp/~molbio/english/e_index.html


  Professor
Yukiko Gotoh
  Assistant Professor
Yasuhiro Itoh
  Assistant Professor
Yusuke Kishi

Recent Publications

  • Nature Communication 2013, 4, 1880. [PDF]
  • EMBO Journal 2013, 32, 970-81. [PDF]
  • Nature Neuroscience 2013, 16, 416-25. [PDF]
  • Nature Neuroscience 2012, 15, 1127-33. [PDF]

Research

Our first research goal is to understand the molecular basis of brain development with an emphasis on the regulation of neural stem cell fate. Our second goal is to understand intracellular signal transduction pathways that regulate cell proliferation, survival and migration, and their involvement in tumorigenesis. These two areas are often closely interconnected.

Regulation of neural stem cell fate :

The central nervous system is composed of various neuronal and glial cell types, which are derived from common progenitor cells called neural stem cells (NSCs). NSCs attract much attention, since their regulation is the key to understand brain development and they are a vital source of brain repair in the regenerative medicine. We are tackling fundamental questions concerning the nature of NSCs: What molecular mechanisms define stemness? How do NSCs produce appropriate cell types in a temporally and spatially defined order? Where do adult NSCs come from?


Functions of the proto-oncogene Akt :

Akt is a serine/threonine kinase whose activation is often associated with malignant cancers. It has been suggested that Akt promotes tumorigenesis via aberrant promotion of cell survival. We found that Akt is prerequisite for growth factor-stimulated migration of fibroblasts, which might also account for the tumorigenic activity of Akt. We are investigating the mechanisms by which Akt regulates cell survival and migration.